13609 Sk Muscle Outline

13609 Sk Muscle Outline - acetylcholine esterase examples:...

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MUSCLE I. Overview Types: skeletal (slow, fast, oxidative, glycolytic), smooth and cardiac Actin and myosin ATP --> ADP + Pi + energy (work + heat) Contraction, shortening generates force Relaxation, stop contraction; return to resting length requires "pull" by antagonistic muscle II. Skeletal Muscle Tissue and cellular structure: multinucleated cells = fibers; motor units = nerve + all cells innervated; no gap junctions G and F actin and myosin - heavy chain [head (fast or slow ATPase) and tail] and light chain sarcomere: A and I bands, Z-line, M-line, H-zone regulatory: tropomyosin, troponin (C, I and T) other structural: nebulin, titin sarcoplasmic reticulum (SR) and T-tubules Sliding filament model A bands constant, I bands shorten length-tension diagram Electrical activity action potential: V-dependent K and Na channels motor nerve and neuromuscular junction acetylcholine (ACh) and synaptic vesicles release nicotinic ACh receptor: ACh binding --> depolarize --> action potential
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Unformatted text preview: acetylcholine esterase examples: curare, nerve poisons, botulinum toxin, tetanus toxin excitation-contraction coupling T-tubules and Ca channels/DHP receptors SR and ryanondine receptors (RyR-Ca channels), Ca release (regulate contraction - Tn) Ca uptake by SR Ca-ATPase (SERCA): Ca bound to calreticulin and calsequestrin Summary: nerve, NM junction, action potential, EC coupling, contract and relax Regulation twitch, summation, tetanus motor unit use and coordination isometric vs. isotonic vs. eccentric contractions muscle types slow twitch, oxidative, red, posture fast twitch, oxidative, red, walking and endurance fast twitch, glycolyic, white, jumping and weights energetics mitochondria glycolysis creatine kinase reaction adenylate kinase reaction fatigue exercise-induced changes in muscle structure clinical examples: hypocalcemic tetany, muscular dystrophy, malignant hyperthermy...
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