13609 Muscle Q+A -...

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S KELETAL , C ARDIAC AND S MOOTH M USCLE - S TUDY G UIDE AND Q UESTIONS Be able to distinguish anatomical and molecular structures of skeletal, cardiac and smooth muscles, including sarcomeres, intercalated discs, gap junctions, Z-lines, actin, myosin, troponin, tropomyosin, nebulin and titin, RyR, transverse tubules, Ca-ATPase (PMCA and SERCA), phospholamban, Na/Ca exchanger, single unit vs multi-unit smooth muscle and role of gap junctions, slow wave vs action potentials in control of smooth muscle contraction. Describe the interactions between Ca and Tn that give rise to control of skeletal and cardiac muscle contraction. For smooth muscle describe the Ca-CaM-MLCK mechanism for regulating contraction. Define for skeletal muscle fast twitch vs slow twitch and glycolytic vs oxidative. Which types of muscle are used for rapid, heavy lifting (weight lifter) vs. rapid, consistent contraction (long distance running) vs. slow, continual contraction (posture) Silverthorn: Chapter 12, all questions and answers but OMIT 21, 22, 25, 32, 33 and 35 Chapter 13, all questions and answers but OMIT 3-8, 13, 15, 17 AND 20-22 1. What would happen to cardiac and smooth muscle contractility and excitability when treated with drugs that block Ca channels in the plasma membrane? 2. Offer explanations for why epinephrine increases: contraction strength and rate of relaxation of cardiac muscle. 3. Name the different functions of ATP during normal contractile cycle of the heart. 4. T or F? Fatigue of cardiac muscle is caused when [ATP] decreases to zero. 5. Caffeine causes the RyR to release Ca and also has effects on cAMP metabolism (see signaling). What might caffeine do to the heart's contraction?
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This note was uploaded on 05/07/2009 for the course MCB 58168 taught by Professor Thorner during the Spring '09 term at University of California, Berkeley.

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13609 Muscle Q+A -...

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