Lecture-27 - Behavioural Pharmacology Behavioural...

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Behavioural Pharmacology Behavioural pharmacology is the study of changes in behaviour produced by a drug, and the mechanisms by which the drug produces these changes. Ultimately we are concerned by the behavioural effects of drugs in humans, but we perform initial screening tests in animals. A wide variety of types of tests are available to assess the behavioural responses of animals to drugs. Types of behaviours 1. Instinctive (eg. eating, aggression, sexual behaviours) 2. Learned (eg. mazes, bar pressing)
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Instinctive behaviours 1. Locomotion: (a) total distance traveled by an animal, (b) the number of revolutions of a rodent running wheel or (c) the number of sectors of a (gridded) open field that an animal enters. 2. Sensory function: hot-plate and tail-flick tests 3. Food & water intake: amounts and patterns of consumption. 4. Aggressive behaviour: (a) count # of spontaneous attacks, (b) # of dominant or submissive postures, (c) shock-induced aggression. 5. Sexual behaviour: measure frequencies of (a) lordosis in females, (b) mounting, intromission , ejaculation in males.
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Lecture-27 - Behavioural Pharmacology Behavioural...

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