test 2 answers - spring 2009

test 2 answers - spring 2009 - Principles of Drug Action...

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Principles of Drug Action (BIO 365) Test #2 Name:_____________________________ March 27, 2009 Each of the 16 multiple choice questions is worth 0.75 marks out of 30 . 1. Which one of the following is NOT a general characteristic of ionotropic receptors? A. They activate kinases. B. They contain membrane-spanning domains. C. They have a rapid onset of action. D. They desensitize rapidly. E. They are made up of several different proteins (subunits). 2. p53 is which one of the following? A. A cancer-causing gene B. An oncogene C. A proto-oncogene D. A tumor suppressor E. A type of cancer cell 3. You are a physician treating an twelve year-old child who weighs 40 kg. If the adult dose of the drug you wish to prescribe is 10 mg/day how much drug should you give this child? A. 5 mg/day according to Young’s rule and 7 mg/day according to the body surface area calculation B. 7 mg/day according to Young’s rule and 5 mg/day according to the body surface area calculation. C. 10 mg/day according to Young’s rule and 7 mg/day according to the body surface area calculation D. 7 mg/day according to Young’s rule and 10 mg/day according to the body surface area calculation. E. 5 mg/day according to Young’s rule and 5 mg/day according to the body surface area calculation. 4. An individual dies of an overdose due to taking alcohol and barbiturates simultaneously. Which of the following terms best describes this kind of drug interaction? A. Internal B. Physicochemical C. Pharmacological D. Pharmacodynamic E. Pharmacokinetic 5. In a recessive disorder, if the frequency of a particular allele is 0.15, what percentage of people in the population are carriers of that allele? Hint: In your calculation don’t include people who are homozygous and actually have the disorder. A. 12.8% (0.15 x 0.85) B. 25.5% (0.15 x 0.85 x 2) C. 15% D. 72.3% (0.85 x 0.85) E. 2.3% (0.15 x 0.15)
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6. Which one of the following statements is TRUE ? A. The acetylcholine molecule can convert between the cis and trans forms because of the double bond in its structure. B. Atropine is an antagonist at muscarinic, but not nicotinic, ACh receptors because its chemical structure permits it a great deal of intramolecular rotation. C. Atropine can adopt either the cis or trans form and this determines whether it will interact with muscarinic or nicotinic acetylcholine receptors. D Optical isomers of drugs are those that have at least three points of attachment to receptors, and have either a centre or plane of asymmetry. E The levo ( l ) isomers of morphine and methorphan are non-addicting. 7. Which one of the following statements is TRUE ? A. There are no known antagonists of metabotropic receptors. B. Metabotropic receptors act by opening an ion channel that is an intrinsic part of the receptor/channel complex. C.
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test 2 answers - spring 2009 - Principles of Drug Action...

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