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Psych 304 Lecture Notes - March 24th

Psych 304 Lecture Notes - March 24th - PSYC 304 Lecture...

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PSYC 304 Lecture Notes March 24 th , 2009 Animal Models Ethics: Research must be humane and worthwhile - kept in good health - comfortable sanitary conditions - anesthetics/analgesics - surgery and antibiotics - appropriate diets - Strict regulations about the care of animals o Permission from ethics board o Periodic inspections Three types of Animal Models are used in Medical Research 1) Homologous a. Animals duplicated human disorders in every respect b. Etiology (cause of disorder), symptoms, and prognosis resemble human (some aspect of the disorder is resembled) 2) Isomorphic (only some types of disorders that can be artificially induced in lab) a. Resemble human disorders but are artificially produced in lab b. Not normal etiology 3) Predictive a. Don’t resemble human disorders but are of value in predicting same aspects of the disorders (ie: response to various drugs) How do we choose which animals? - outstanding features - convenience (ie: fruit flies b/c they’ve been widely studied, short life span, easy to maintain….) lab rats are also convenient b/c relatable to humans, breed well, inexpensive, reared in lab and bred in lab thus, are very similar to one another. - comparison - preservation (see pg 163 box 6.2) - economic importance
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- treatment of disease - 93% of mammals used in research are laboratory-reared rats Some things we research… - Alzheimer’s Disease - Epilepsy - Parkinson’s Disease - Memory Medial temporal lobe and declarative memory - H.M. (removed bilateral temporal lobe bilaterally, has retrograde and anterograde amnesia) - Identify structures involved w/ memory - Precise lesions - Control what & when subjects learn - How and when retention is tested -
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