Psych 304 Lecture Notes - Jan.13th

Psych 304 Lecture Notes - Jan.13th - Psych 304 Lecture...

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Psych 304 Lecture Notes Jan.13 th , 2009 Melatonin: - many hormones have a rhythm: - circadia: “around a day”; 1 day rhythm - cirannual: 1 year rhythm - melatonin has a circadian rhythm (increased during the night, decreased during the day) - 3 cycles must occur in order to say something is in a “rhythm” (either 3 days for the circadian rhythm or 3 years for the cirannual rhythm, 3 months in a row for menstrual cycle, etc.) - during the day, there is no melatonin secretion (only produced during the night) - tryptophan: essential amino acid, needs to be taken in (diet), body cannot produce it - melatonin is an endolin (monoamine) - both going to sleep & turning off the light causes melatonin secretion - sleep studies are very difficult because sleep must be studied many nights (not just one night) - studying rats in the lab is inappropriate because they are being studied during the day (rats are nocturnal animals) - there are differences between people in melatonin secretion amount, but within an individual, melatonin secretion is characteristic (always the same) - controlled through adrenergic enervation (neurotransmitter) - beta-blockers can control serotonin - melatonin does NOT efficiently help with arthritis, sexual function, immune disorders, etc. - melatonin is secreted by the pineal gland Pineal gland in humans: 50-200mg (very small) - outside the blood brain barrier (bbb) - calcified in adults → significance? (normally calcified body parts are non-functional) - Lerner: pathophysiology and treatment of vitiligo (reduced pigmentation in the skin; splotchy skin) - secreted at night in both nocturnal and diurnal species - bright light (>2500 lux) suppresses melatonin (MEL) in humans (in hamsters, very dim 0.1 lux 1 msec ~1/2 moon) - biological rhythms (of melatonin) - no effect of nutrition, metabolic changes and stress on melatonin secretion - melatonin production under adrenergic control - catabolism (degradation) of melatonin occurs in liver and kidney - melatonin levels decrease after puberty and stabilize before declining in old age - physiological role of melatonin in humans remains undefined (sleep, thermoregulation, phase shift
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This note was uploaded on 05/09/2009 for the course PSYC 304 taught by Professor Comeau during the Spring '08 term at The University of British Columbia.

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Psych 304 Lecture Notes - Jan.13th - Psych 304 Lecture...

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