Midterm_I_review - Innate versus Adaptive Immunity Midterm...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Midterm I Review MCB50 Midterm I Innate versus Adaptive Immunity Characteristics of Adaptive Immune System Memory Self/nonself differentiation Antigen speciFc Cells of the Immune System T and B cells are the antigen specific cells of ADAPTIVE IMMUNITY Innate Immune System Innate Immunity is primarily non-antigen speciFc immune response. Examples Include CELLS--- neutrophils, macrophages, dendritic cells. MECHANISMS-- in±ammation, phagocytosis, mucus. MOLECULAR MEDIATORS--enzymes, oxygen radicals, cytokines.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Acute Inflammation Redness Pain Swelling Heat Triggered by tissue damage or presence of pathogens. Initiation of Acute Inflammation Vasodilation – Increase in the diameter of blood vessels. Increased capillary permeability – Allows inFux of Fuid and cells into tissue. InFux of inFammatory cells – Neutrophil and macrophages to site. What does Inflammation do? Signals body to send cells to site. If no infection, innate immunity cleans up and repairs area. If foreign infection, innate immune cells need to initiate adaptive immunity. Neutrophils Phagocytosis Produce oxygen radicals and enzymes for killing. Short lived cells --”suicide bombers”
Background image of page 2
3 Acute infammation Activated Macrophages activated by cytokines From Th1 cells or phagocytosis •Produce oxygen radicals and enzymes For killing. •Antigen presentation and costimulation For T cell activation. •Produce abundant IL-1, IL-6, TN±- α Systemic Acute Inflammation IL-1 IL-6, TNF- α Large amounts oF IL-1 IL-6, TNF- α can cause many disseminated eFFects. Some good such as Fever, increased metabolism.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/13/2009 for the course MCB 50 taught by Professor Beatty during the Spring '09 term at University of California, Berkeley.

Page1 / 10

Midterm_I_review - Innate versus Adaptive Immunity Midterm...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online