HW08 - In the line-angle structure given below wedges and...

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CH 310M/318M Spring 2008 Last Name: First Name: Dr. Bocknack UTEID: Score: Please circle the section in which you are registered ! POINTS MAY BE DEDUCTED IF YOU DON’T ! MWF 9:00 TTh 8:00 Graded Homework Problem #08 Deadline : 3:00 p.m., Thursday, 2/28/08 LATE WORK WILL NOT BE ACCEPTED OR GRADED!!! This problem is worth a total of 20 raw points. Each box is worth 4 points. The molecule shown below is Spironolactone, which is a potassium-sparing diuretic that is used in the treatment of edema, cirrhosis of the liver, and hypokalemia (low concentration of potassium in the blood). Sales of this generic medication reached $147.0 million during 2006.
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Unformatted text preview: In the line-angle structure given below, wedges and dashed wedges are used to indicate absolute stereochemistry. Look at the structure of Spironolactone, and determine the total number of chiral centers present in this molecule. Write your answer in the appropriate box. Several (but not all) of these chiral centers are marked with arrows. In the box associated with each arrow, indicate the stereochemical configuration of the chiral center as ( R ) or ( S ) . Total number of chiral centers present = O O H 3 C H H 3 C S H H O O Spironolactone...
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This note was uploaded on 05/14/2009 for the course CH 310M taught by Professor Iverson during the Spring '05 term at University of Texas.

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