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Unformatted text preview: Lecture 15 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Define the following terms [including what cell(s) the term applies to, as appropriate]: fix complement initiate binding of complement (IgM) poly-Ig receptor - binds Ch3 domain of IgA on epithelium J-chain holds 2 identical monomers of IgA together secretory component little portion of poly-Ig-receptor remains attached to IgA dimer Fc fragment of an Ab, most readily crystallized FcR Fc receptor 2) Provide examples of the major functions of antibody (including neutralization, opsonization, and complement fixation) Neutralize toxins and/or pathogen binding to cells Opsonization target for phagocytosis Complement activation for direct lysis or clearance by M0 lineage cells 3) Identify the 3 major antibody isotype(s) in body fluids and specifically indicate whether each isotype is confined to the bloodstream or can enter tissue fluids....
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This note was uploaded on 03/22/2008 for the course MT 434 taught by Professor Hoag during the Fall '07 term at Michigan State University.
- Fall '07