Lecture_30_Objectives

Lecture_30_Objectives - Lecture 30 Objectives At the...

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Lecture 30 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Identify whether CD4 + T cells, CD8 + T cells, and/or B cells are responsible for autoimmune disease. Both autoimmune Abs and Tcells (Tc) have been found to be responsible, b/c of requirement for T cell help in Ab production all persistent autoimmunity must be due to breach in Th cell tolerance 2) Identify the 2 autoimmune diseases that have a much higher incidence rate (> 5 times) in women than in men. MS and graves disease 3) Define "relative risk" and the ultimate effect that it has on an individual's likelihood to develop any given autoimmune disease. RR = if you have an associated HLA type RR is the increased risk you have over the gen pop of getting the disease 4) List and explain the mechanism of at least seven (7) factors that have been proposed to be triggers for autoimmune disease development. Inflammation causing ectopic exp of MHC II on cells that would norm not express it,
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This note was uploaded on 03/22/2008 for the course MT 434 taught by Professor Hoag during the Fall '07 term at Michigan State University.

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Lecture_30_Objectives - Lecture 30 Objectives At the...

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