Lecture_25_Objectives

Lecture_25_Objective - Lecture 25 Objectives At the completion of the lecture and the assigned reading the student should be able to 1 Define the

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Lecture 25 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Define the following terms [including what cell(s) the term applies to]: nontreponemal tests – use test Ag consisting of a soln of cholesterol, lecithin, and cardiolipin to detect regain Abs (non-specific Abs to cardiolipin) treponemal tests – detect Ab specifically to treponemal Ags reagin - non-specific Abs to cardiolipin 2) Identify the causative agent of Lyme disease, the characteristic symptom of primary infection that is observed in 80% of patients, and disease sequelae that may be seen in chronic infection. Caused by spirochetes (bacteria) Borrelia burgdorferi, erythema chronicum migrans rash = bull’s eye rash , seen in chronic infection migratory pain in joints, tendons, muscles, and bones – neurologic or cardiac involvement approx 6 wks after onset of infection – most common chronic symptom is large joint arthritis 3) Identify the screening test for Lyme disease, whether a positive is diagnostic, and whether a confirmatory test is necessary (if so, ID the confirmatory test). Lack sensitivity and specificity (85% actually have when test positive other 15% =
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This note was uploaded on 03/22/2008 for the course MT 434 taught by Professor Hoag during the Fall '07 term at Michigan State University.

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Lecture_25_Objective - Lecture 25 Objectives At the completion of the lecture and the assigned reading the student should be able to 1 Define the

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