Lecture_28_Objectives

Lecture_28_Objectives - Lecture 28 Objectives At the...

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Lecture 28 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Identify which types of hypersensitivity responses can cause autoimmune disorders, and which of these is most commonly encountered. Type II-IV responsible for autoimmune disease 2) Be able to match the autoimmune endocrine disorders (Grave’s disease, Hashimoto’s thyroiditis, Addison’s disease, Type I diabetes) with the auto- antibodies that may be observed in each disease, the serological testing done to diagnose the disease (if appropriate), and the immune mechanism that is responsible for the observed pathology. Grave’s – due to Ab to thyroid stimulating hormone receptor (anti-TSH-R) Ab acts as ligand and stimulates excess T3 and T4 secretion feedback mech no longer works most commonly done w/o need for serological testing Hashimoto’s throiditis – auto Ab is found but Tcell destruction of thyroid epithelial cells is thought to cause the disease detect 1 of 2 primary autoAbs is key
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Lecture_28_Objectives - Lecture 28 Objectives At the...

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