Lecture_29_Objectives - Lecture 29 Objectives At the...

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Lecture 29 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Identify the two most common rheumatologic diseases that are considered autoimmune diseases. RA and lupus 2) Explain why autoimmune rheumatologic diseases are difficult to diagnose. Overlap in symptoms from one disease to another, and overlap in test results (no test completely specific or sensitive for disease not all pt have the expected autoAbs) 3) Define “rheumatoid factor” (RF) and identify what diseases it may be found in, and for which disease it is considered most significant. RF = IgM IgG or IgA Ab to the Fc portion of IgG (antiimmunoglobulin Abs) – make autoAb against own Ab form immune complexes in joint fluid 4) Describe the inflammatory infiltrate that is observed in the joints of individuals with advanced rheumatoid arthritis (RA) and the eventual result this has on the joint tissue itself. CD4, CD8, Tcells, Bcells, plasma cells, neutrophils, M0’s all infiltrate the joint cell mediated response against self Inflammatory cells secrete prostaglandins and leukotrienes that increase inflammation Neutrophils degranulate in joints release proteinases and collagenases that digest the cartilage and eventually erode the bone 5) Identify the diagnostic criteria used for RA and whether it is necessary for the RF
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Lecture_29_Objectives - Lecture 29 Objectives At the...

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