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Unformatted text preview: Lecture 17 Objectives At the completion of the lecture and the assigned reading, the student should be able to: 1) Define the following terms [including what cell(s) the term applies to, as appropriate]: NK cells target via various KIR and NCR family receptors KIR – killer cell Ig like receptors bind self class I and can act as inhibitory or activating receptors NCR – natural cytotoxicity receptors activating rec with mostly undefined ligands. 2) Be able to recognize examples of mechanical, chemical and microbiological innate barriers to infection that have been identified in epithelial tissues. Table page 89 3) Match the time for activation of innate and adaptive immune responses to either “<24 hours” = innate “days” = adaptive 4) Define “chemokines” and the two signature amino acid sequence motifs that characterize the chemokine family. Chemokines are secreted in sites of inflammation attract immune cells CXC chemokines – attract naïve T cells and neutrophils, can control...
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- Fall '07
- acute phase, activates NK cells, immune cells CXC, effector cells TNF