Asudomsoct6-7 - Microbiology2.docx - Asudomoct6 o...

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Asudomoct6
oPenicillin G and VV goes with oral, not with IVoMOA?Cell wall inhibitoroDuring laborpencillin type durgs to mothers whoare gropu B positiveGBSneonatal infectionoIf someone has syphilis,penicillinGram positive org’sS. pneumoniaS. pyogenesActiomyces speeGBSSpirochetesSyphilisGram positive rods:ClostridiumListeriaBaccilus sppGram negative cocciNeisseria sppo
oMethicillinPenicillinase:subatnce produced by somebacteriabreak down penicillinoCUS. aurerusMSSA and MRSAoMRSA:If you can’t bind to it, you can’tkill it.oPenicillinase?Hydrolysis the beta-lactam ring ofpenicillindrugs.Aka?Penicillin beta-lactamase.
Where do bacteria produce thispencillinase?oPeripalsm of cellscoated byplasmidsoCombin e aminopenicilin with to enhance ethierspectrum?Clavulanic acid (penicillinase inhibitor)Clavulanic acid + amoxicillin =augmentin.oChildrenear infectionEspecially in resistant earinfectionsTazobactamSulbactum
Ampicillin + sulbactam =unasyn.oThis is an IV medicationused insurgery to help with surgicalinfections.CU:oGram positive bacteriaoGram negative rods:HELPSSoUTIE. coliEnterocciProteus mirabilisoNeonatal infection:GELGBSE. coliListeriaoi.e. ampicillin: IV form of ampicillinoften used in combiatoin withgentamycinbaby is septicotoxicity:ampicillin/amoxicillin rashif pt hasmononucleosisaminopenicillinfull body rash.o20% of mono pt’s have strept throattoo.
If someone has mono, don’t justgive them an aminopenicillin.oPt will think they’re allergic toamoxicillin when they get this bigrash, MONONormal reaction from the monoand aminopencillinMCC?oEBVAnother toxicity?Pseudomembranous colitis:oWhat bacteria causes PC?Clostridium difficileoAntibiotics kill a majorityendogenous bacteria in the gutC.difPC.
oAka carboxypenicillins
oAs you increase generation from 1 to 4increasegram negative coveage. But you also decreasegram positiveo1stgeneration CUTI’sRx? CephalexinWith aminopencillinprophylaxisviridians streptocossusendocarditisoSo pt’s with abn heart vavlerubulent blood flow in their heart.take antibioticsprevent bacterendocarditis during dental procedureRx?

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Term
Spring
Professor
N/A
Tags
Microbiology, Bacteria, pH, Usmle, Syphilis, gram negative bacteria

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