Asudomsept16 - Pharmacology Neurotransmitters.docx -...

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Asudomsept16What happens to Ach when it gets to the synapse?
What drugs inhibit a-esterase?
NoradrenergicoTyrosine comes into the cell? Cotransporting?
Sodium (tyrosine use the sodium gradient to go intothe cell)oThere is an enzymes the converts tyrosin into DOPA?Tyrosine hydroxylaseoWhat inhibits T.H?Metyrosine.Precursor of tyrosine?oPhenylalaiineWhich is A.A. and becomes tyrosineTyrosine is converted to thryoxine, which isyour thyroid hormoneTyrosine is also converted to L-DOPAoL-DOPAmelaninoL-DOPAdopamine, then Ne, then to EpioTyrosine being converted to DOPA by?Tyrosine hydroxylase,Then L-DOPA is converted to dopamineTyrosine being converted to DOPA by? T. H-ase.oDopamine is converted to NE and packaged ito vesicles.What inhibits this process of conversion from DA toNE packaing into vesicles?Reserpine.
What cause sthe vesicles to bind to P.M release it’scontents into stynapes?
What subatnce inhibits the reuptake of NE?
what subatnces inhibits the release NE?
what subatnce inbhits the binding/fusion of vesciel to theplasma menbrae int eh release of NE?
what inhbits the fusion of vesicle of plasma membrane andrelease of NE?
what stimulates the release of NE?
AlphaoAlpha1oAlpha2BetaoBeta1oBeta2o2) bind to a presyanptic autoreceptorMuscarinic 2 (M2) receptorsInhibit NE reeleaseAlpha2 receptorsinhibits release of NEAngiotensin II (ATII)stimulates release of NEIncrease BPoBlood vesselsconstrictsBlood vessels the dominant tone?Sympathetic tonestimulatingATIIstimulate NE release andyou will have morecontraction.o3)reuptakeit can be taken back up by the presynaptic cellcan inhibit process?oTCA, cocaine, amphetamineo4)MetabolizedNE can be metabolizedoCOMT (catechol-O-methyltransferase)MethylatesNEoMAO (monoamine oxidase)OxidizeNE
What drug inhibit MAO?
These will prevent the metabolismof?
TCA’s MOA?

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