Ch. 11, Pharmacology.pptx - NTD 413 PHARMACOLOGY FOOD-DRUG INTERACTIONS Introduction to Pharmacology Pure Food and Drug Act 1906 Food Drug and Cosmetic

Ch. 11, Pharmacology.pptx - NTD 413 PHARMACOLOGY FOOD-DRUG...

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NTD 413 PHARMACOLOGY & FOOD-DRUG INTERACTIONS
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Introduction to Pharmacology Pure Food and Drug Act 1906 & Food, Drug, and Cosmetic Act 1938 began government regulation for drugs 2/3 doctor visits include prescriptions Complementary and alternative medicine (CAM)
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Introduction to Pharmacology Pharmacotherapy – use of drugs for the treatment of disease and health maintenance Pharmacology – study of drugs, properties and their effects Pharmacokinetics – study of drug absorption, distribution, metabolism and excretion
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Role of Nutrition Therapy in Pharmacotherapy Nutrition affects drug action Drug action affects nutrition “Drug-nutrient” interactions Preventing interactions is one part of nutrition assessment/pharmacotherapy
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Administration of Drugs Sublingual or buccal – mouth or cheek e.g. nitroglycerin Parenteral SC, ID, IM, IP, IV Topical – skin or mucus membrane Inhalation Directly to target tissue Opthalmic, otic, epidural or intrathecal
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Pharmacokinetics Absorption of Drugs Same basic processes as nutrients Passive diffusion, facilitated diffusion, active transport Solubility – where in GI tract meds will dissolve and be absorbed Ionization – non-ionized drugs are absorbed more readily; ionized will absorb more readily in similar pH Excipients – substances added to meds that affect dissolution (dissolving) Binders, lubricants, coating, coloring, flavor, tablet formulation
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Pharmacokinetics Absorption of Drugs (cont.) Time, pH, and surface area of GI tract Chemical properties Integrity of GI, circulation of blood
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Pharmacokinetics Distribution of Drugs Movement throughout body to target tissue Affected by circulation, and binding Greater binding = less active drug in
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