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07Fexam3key

# 07Fexam3key - Name_KEY EID CH 339K Exam 3 11 Oct 2007 100...

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Name______________ KEY ___________________________ EID__________________________________________ 1 CH 339K Exam 3 11 Oct 2007 100 points total 1 . The following data describe the binding of oxygen to human myoglobin at 37°C: P O2 (pascal) θ 66.5 0.161 133 0.277 266 0.434 399 0.535 532 0.605 798 0.697 1064 0.754 1596 0.821 2660 0.885 From these data, estimate the following (use attached graph paper if necessary): 10 pts. a . P 50 (the P O2 that gives θ = 0.5) is approximately 350 pascal 5 pts. b . the fractional saturation of myoglobin at 4 kPa, the partial pressure of O 2 in venous blood. According to the graph, extrapolation to 4 kPa (4000 pascal)would give a θ something above 0.9, approximately 0.92. 0 500 1000 1500 2000 2500 3000 3500 4000 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 P 50 ~ 350 pascal ~0.92 P O2 (pascal) !

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Name______________ KEY ___________________________ EID__________________________________________ 2 2 . Shown below is a Hill plot for the oxygen binding by hemoglobin of the shrimp Callianassa . -2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 2.0 2.5 3.0 -3.0 -2.5 -2.0 -1.5 -1.0 -0.5 0.0 0.5 1.0 1.5 determine n from slope of this line log P O2 (kPa) log ( ! /1- ! ) 10 pts. a . Determine the P 50 (in kPa) for this hemoglobin. Hint: according to the Hill equation (equation 5-17, p. 167), when log ( θ /1- θ ) = 0, n •log P O2 = n •log P 50 n •log P O2 = n •log P 50 , so P 50 = P O2 when log ( θ /1- θ ). Log P O2 ~ 1.2 10 1.2 ~ 15.8 kPa 5 pts. b . Indicate, by drawing a line-of-best-fit through the appropriate data points, where you would determine the Hill coefficient,
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07Fexam3key - Name_KEY EID CH 339K Exam 3 11 Oct 2007 100...

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