lecture 4 (01.23.18) Ig structure and function.ppt

lecture 4 (01.23.18) Ig structure and function.ppt -...

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Repertoire Development The B Cell Antigen Receptor: Immunoglobulin Dr. Michael Shaw Assistant Professor Department of Immunology and Microbiology Director of Research- Osteopathic Division Director, Basic Science Facilities St John Health System 248-849-3968 (office) [email protected] [email protected]
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B Cell Antigen Receptors: Repertoire Development Immunoglobulin Structure Immunoglobulin Function Generation of Diversity Receptor Development
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Innate and Adaptive Immunity
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Adaptive Immunity : Benefits Allows the individual to adapt and fight off pathogen that innate immune processes fail to eradicate Allow the individual to adapt immune responses to changing pathogens (HIV, malaria, etc.) Allow specific immune responses—immune responses are VERY damaging if left uncontrolled (autoimmunity…). Innate immune responses are by nature quite benign.
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Characteristics of an adaptive immune Characteristics of an adaptive immune response response 4. Self/non-self discrimination-the immune system does not react with self antigens in a deleterious manner 1. Antigenic specificity-the immune system responses with exquisite specificity NH 2 NH 2 NH 2 NH 2 2. Diversity—the immune system can respond to nearly any antigen, even though not normally found in nature (ie. Man made compounds such as dinitro-phenols, and very small antigens such as metal ions) NH 2 NH 2 3. Immunologic memory-the secondary response to an antigen is faster, more specific and more effective than a primary response. This usually results in life long immunity to a second infection with the same pathogen
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Innate and Adaptive Immunity
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Adaptive Immunity: B Cell Receptors-An Overview Each cell displays a single distinct antigen receptor Complex process occurs in the BM to create the large number of receptors needed (G.o.D.) Aberrations in the production, function or expression of these receptors can cause pathology (allergy, organ transplant rejection, lupus, Ig deficiency, multiple myeloma) Two distinct functions—antigen binding, effector function Historical context (starting about 1890)
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Discovering the immunoglobulin molecule: Immune responses cause an increase in serum gamma globulin Transfer of immune serum can transfer immunity (horse serum anti-venom)
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  • Winter '18
  • multiple myeloma, Immunoglobulin Fine Structure

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