Innate immunity_Part II_He.ppt - Innate Immunity-Part II Dr...

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Innate Immunity-Part II Dr. He Scott Hall 5312 [email protected]
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Host immune response to an initial infection 1. Innate phase 2. Early induced innate response 3. Adaptive immune response
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Host immune response to an initial infection 1. innate phase 2. early induced innate response 3. Adaptive immune response
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Recognition of PAMPs Activation of innate immune cells and inflammation Recruitment of innate immune cells Early induced innate response
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Microbes are recognized, ingested, and killed by phagocytes
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Microbes are recognized, ingested, and killed by phagocytes
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Neutrophil extracellular traps (NETs) trap pathogens
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Bactericidal agents produced by phagocytes and antimicrobial mechanisms
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G-protein-coupled receptors on phagocytes link microbe recognition with increased efficiency of intracellular killing
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Infection stimulates macrophages to release cytokines and chemokines that initiate an inflammatory response
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Neutrophils make up the first wave of cells that cross the blood vessel wall to enter an inflamed tissue
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Neutrophils make up the first wave of cells that cross the blood vessel wall to enter an inflamed tissue
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Monocytes circulating in the blood are recruited to infection sites
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  • Winter '18
  • Adaptive immune response, innate immune cells, host immune response, Mammalian Toll-Like Receptors

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