NR 283 Unit 2 ROK Immunity and inflammation Hypersensitivity revised.docx

NR 283 Unit 2 ROK Immunity and inflammation Hypersensitivity revised.docx

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Atlanta Campus Review of Knowledge Review of Knowledge (ROK) (25 Points) Course NR 283 Exam Exam 1 Purpose The Review of Knowledge (ROK) focuses on course outcomes, unit outcomes and key concepts to enhance student success on exams. Use this document as a focused guide for study in conjunction with assigned readings, PowerPoint presentations, and other course resources. Supplement this document by outlining your own notes from the textbook chapters and place your expanded more detailed notes in the Student Notes column. This document should NOT be used as a substitute for completing the assigned readings. Chapter 5-7 Inflammation and immunity (10 Points) Key Concepts Chapters Student Notes Innate Immunity Adaptive immunity Acquired immunity Specific immunity Wound healing Inflammatory Chapter 5, 6, 7 (specific portions) Innate Immunity = immunity that one is born with. Thymus plays a large part in formulating this immunity. Also the white blood cells are involved in this type of immunity. Adaptive Immunity = immunity that develops slowly after exposure to a specific pathogen. The lymphocytes create a specific antibody for the pathogen. They adapt to that exposure. Acquired Immunity= immunity that develops after exposure to a suitable agent. (i.e) attacked by a disease or by injection of antigens (immunizations) Specific Immunity = is a subsystem of the overall immune system that is composed of highly specialized systemic cells & processes that eliminate or prevent pathogen growth. Wound healing- involves a series of steps. Homeostasis Inflammation-mast cells-histamine released Proliferation-neutrophils are called to fight the bacteria- macrophages will come in phagocytize bacteria-t-helper take protein to lymphocytes and lymphocytes will make antibodies- antibodies create lock and key-humoral immunity. Remodeling phase Platelets play a key role in forming clots and stop the bleeding. Mediators of Inflammation Chemotaxis -Movement of cells or organisms in response to POET - ROK Form Revised 5.3.16 1
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process Chemotactic factors chemicals. Examples of the chemicals are histamine, bradykinins, leukotriene, cytokines (Many different types, ex. interleukins, TNF), prostglandins. Leukotrienes from mast cell membranes Similar effects to histamine in later stages Prostaglandins they also induce pain (NSAIDs) block the synthesis of prostaglandins, thereby inhibiting inflammation Bradykinin Causes dilation of blood vessels, pain, smooth muscle contraction, vascular permeability, and leukocyte chemotaxis Cytokines - Attract leukocytes to site of inflammation Synthesized by many cells (macrophages, fibroblasts, endothelial cells). chemicals with increase inflammation Interleukins (IL) Produced primarily by macrophages and lymphocytes in response to a pathogen or stimulation by other products of inflammation Induces fever by acting as an endogenous pyrogen Granulocytes- very grainy Neutrophils are evident in the first stages of an infection or inflammation.
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