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Unformatted text preview: What's the Disease? What's the Microbe? Generates high fevers (up to 107F!!). Induces leathery pseudomembrane in throat, requiring tracheotomy. Common cause of death in the U.S before 1900. Prevented by the DTP vaccine. Still common in the developing world. What's the disease? diphtheria 1 Corynebacterium diphtheriae Diphtheriacausing strains of Corynebacterium diphtheriae are altered by a bacterial virus (bacteriophage b) to express a toxin gene. This is called Virulence Conversion. The diphtheria toxin enters human cells, stops protein synthesis and kills them. DToxin It takes only one molecule of diphtheria toxin to kill one human cell! 2 ...
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This homework help was uploaded on 03/21/2008 for the course PY 211 / 212 taught by Professor Chilton during the Spring '08 term at N.C. State.
- Spring '08