Blood Banking Prelims.docx - Rh Blood Group System 2nd most...

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Rh Blood Group System - 2 nd most important Blood Group System after ABO - Greatest clinical importance in Hemolytic Disease of the Newborn (erythroblastosis fetalis) and Transfusion Reactions - 50 Rh antigens ( Rh 1 -> Rh 57 ) - Come from Rhesus monkey - Most common based on antigenicity: D > c > E > C > e - D – primary antigen, would be Rh(+) or Rh(-) due to this no matter what - Location: Non-glycosylated protein on RBC membrane (Chromosome 1) along with 1. genes for elliptocytosis 2. 6-phosphoglucoronic dehydrogenase 3. phosphoglucomutase 4. phosphopyruvate hydratase - no glucose moity - Autosomal dominant - Difficulty in describing structure - 174,000 MW compound HISTORY - Discovered by Blood Transfusion A. (1939) Levine and Stetson - Antibody of D Antigen (Anti-D) - In serum of woman whose fetus had HDN (second birth) - Mother is Rh(-), Father is Rh(+) B. (1940) Landsteiner and Weiner -Identified the Rh Blood Group System - 85% Agglutinated = Rh (+) - 15% Non-agglutinated = Rh (-) - Ab in Female = Anti-Rh - Ab in Rabbit = Anti-LW C. Weiner and Peter - Rh(-) who received Rh(+) blood are compatible 4 NOMENCLATURES 1. Fischer-Race – DCE Terminology 2. Weiner – rH, Hr 3. Rosenfield – Alpha/Numeric 4. ISBT – Numeric Fisher-Race - 3 closely linked genes that can be inherited from each parent has 3 closely linked loci that carry the Rh genes - Crossing over is rare cause they are closely linked - MNSS - CDE -> cde Weiner - 1 gene at a single locus controls the entire Rh system - D – Rh 0 - C – Rh I - E – Rh II - c – hr I - e – hr II - Has agglutinogen w/c is made up of 3 blood factors - Antigen – subscript Rosenfield - Aims to bridge the confusion between first 2 - A number in chronological discovery - No genetic basis - Presence or absence only of Ag - D – 1 - C – 2 - E – 3 - e – 4 - c – 5 ISBT (International Society for Blood Transfusions) - 6 numerical numbers - 004 = Rh - D – 004001 - C – 004002 - E – 004003 - c – 004004 - e – 004005 1 Pagkatipunan 3A-MT S.Y. 2014-2015 Rh RBC Rabbit Produce antibodies against Rh RBC Ab reaction with human RBC Anti-Rh
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- Possible combina tions - Fisher- Race - Wein er Shorthand - Gene - Agglutin ogen or Ag - 3 blood factors - Rosenfiel d - Dce - Dce - Ro - Rh o - Rh o - Rho, hr I , hr II - Rh 1, -2, -3, 4, 5 - DCe - DCe - R1 - Rh 1 - Rh 1 - Rho, rh I , hr II - Rh 1, 2, -3, -4, 5 - DcE - DcE - R2 - Rh 2 - Rh 2 - Rho, hr I , rh II - Rh 1, -2, 3, 4, -5 - DCE - DCE - Rz - Rh z - Rh z - Rho, rh I , rh II - Rh 1, 2, 3, -4, -5 - dce - dce - r - rh - rh - hr i , hr ii - Rh -1, -2, -3, 4, 5 - dCe - dCe - r I - rh I - rh I - rh i ,hr ii - Rh -1, 2, -3, - -4, 5 - dcE - dcE - r II - rh II - rh II - hr i ,rh ii - Rh -1, -2, 3, 4, -5 - dCE - dCE - rY - rh Y - rh Y - rh i ,rh ii - Rh -1, 2, 3, -4, -5 - - - - Variants of Rh - Cu - Cf - Cw - Eu - Du – Weakened expression of D-Antigen (Blacks>Caucasians) detectable only by Indirect Method. It is few in number - D+w is the phenotype - - Mechanisms of Weak D Antigen - - 1. c-Trans - - C is in cis position with D - - if C is in trans position it causes weak D - - - - Cis Trans - - - - Normal Weak-D - - - - - - - - - - - 2. Partial or Mosaic - - Because Rh is a low MW compound (174,000 daltons), it is said that the D-antigen is a mosaic structure composed of
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  • Fall '14
  • Rh Ag, Rh Blood Group System, Rh RBC

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