39. KKR NPB101 s18- Intro to Endo2 (to post).pdf

39. KKR NPB101 s18- Intro to Endo2 (to post).pdf - 39...

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Lecture 38* EnergyBalance2and IntrototheEndocrineSystem Recommendedreading:Chapter4,pp120*129and Chapter18,pp638*663 39
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Fig.4'20,p.117 Howdothecellsofthebodytalktoeachother? Hormonesand neurohormones = ENDOCRINESIGNALING *eventhoughhormonescirculateinthebloodstream,onlyspecifictarget cellscanrespondtothembecausetheyexpressthehormone’sreceptor e.g.vasopressin
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A hormone isanextracellularsignaling moleculethatis releasedintothe blood andactsatitsreceptorsindistal tissuesinordertoelicitaphysiological response.
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Hormonescanbesecretedby dedicated endocrineglands innon%pregnantadultstheseinclude Dedicated endocrinegland Hormonessecreted Endocrinepancreas(lecture34%35) Insulin,glucagon, somatostatin Pituitary(Lecture38) Adrenocorticotropic hormone(ACTH) Thyroidstimulatinghormone(TSH) Growthhormone(GH) Prolactin Folliclestimulatinghormone (FSH) Luteinizinghormone(LH) Adrenal(Lecture39) Epinephrine andnorepinephrine Cortisol Aldosterone Dehydroepiandosterone sulfate(DHEAS) Thyroid(Lecture40) Tetraiodothyronine (aka T4, thyroxine) Triiodothyronine (akaT3) Calcitonin Parathyroid Parathyroidhormone(PTH) Ovaries(Furlow) Estradiol%17 ! , Progesterone, Inhibin Testes(Furlow) Testosterone, Antimullerian hormone(AMH), Inhibin andseeTable18%2, pp 644%45
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Hormonescanbesecretedbyorganswithaprimary functionotherthanendocrine anon%exhaustivelist Organ Hormonessecreted brackets= justFYI,notforexam White adiposetissue(Lecture36) Leptin [also adiponectin, resistin] Stomach(Lecture32) Gastrin, Somatostatin [alsoGhrelin] Intestines(Lecture33,34) Cholecystokinin,secretin,GLP%1,GIP[alsoFGF19] Kidney(Lecture XX) Erythropoetin Liver(Lecture40) Insulin%like growthfactor%1[alsoFGF21] Brain (hypothalamus,Lecture38) Vasopressin [andoxytocin] Corticotropin%releasinghormone(CRH)
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  • Spring '08
  • Fuller,Charles/Goldberg,Jack
  • Physiology, Triiodothyronine

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