BIOM3200 Lab Case 2.docx - BIOM*3200 Clinical Case Study#2...

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BIOM*3200 Clinical Case Study #2 What Do I know? Signalment: 12 year old cat Female Intact, indoor cat Adopted as a kitten Visits the clinic once a year Vaccination status is current Signs: Weight loss Drinking lots of water Consistently sneezing for the last three days Went from being active to lethargic in three days Dehydrated Emaciated (2.8kg) Firm, 1-2cm, moveable mass which is palpable on the right side of the larynx Problem List (arranged in order from most likely to least likely) 1) Thea Ride is experiencing many symptoms of hyperthyroidism (a common disorder in older cats causing an increased production in thyroid hormones from the thyroid gland): Weight loss Excessive thirst (Polydipsia) Increased heart rate, increase in respiratory rate and capillary refill time Elevated T4, ALT and Alkaline Phosphate Levels Elevated Phosphorus and Neutrophils Levels Enlarged thyroid gland Low Calcium Levels 2) Thea Ride is also experiencing many signs of chronic renal disease (failure of the kidneys to perform their proper functions): Fever (Increased Internal Temperature) Lack of Calcium and Potassium High Creatinine and Urea Levels Elevated Carbon Dioxide Levels Dehydration Elevated Phosphorus Levels Lethargy Excessive thirst 3) Hypertension; often seen with kidney diseases and hyperthyroidism 4) Dental Disorders; a result of kidney failure and its metabolic acidosis creating ulcers in the mouth 5) Thyrotoxic heart disease; a result of too much thyroid hormone affecting the heart 6) Feline Immunodeficiency Virus (a complex retrovirus that causes immunodeficiency disease in cats): Fever Sneezing Lethargy However, Thea is not experiencing these symptoms: Oral Infections Skin Infections Neurologic Disease
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What is Going On? Diagnosis: Hyperthyroidism influencing Chronic Renal Disease- Stage 2 Mild Renal Azotemia Why the high internal temperature? Substances that cause fever are called pyrogens. Pyrogens cross the blood brain barrier and bind to neurons in the thermoregulatory centre. Higher temperature is meant to buy the immune system time to subdue the infection/inflammation. This would be a result of the inflamed thyroid gland.
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