L21_2017_CaseStudiesEvol_student version220.pdf

L21_2017_CaseStudiesEvol_student version220.pdf - BIOL1020...

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BIOL1020 A/Prof Cynthia Riginos and A/Prof Sandie Degnan School of Biological Sciences Lecture 21 Case studies in Evolution Readings : Campbell 22.3-22.4 (Review 22.1 - 22.2)
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Learning objectives for today s lecture: 1. To discuss how mechanisms of evolution affect genetic variation in populations, with sickle cell anemia as an example 2. To start developing an understanding for how evolutionary processes and evolutionary history affect all aspects of biology and many aspects of human wellbeing Keywords : evolution, selection, genetic drift, population genetics, gene flow 2
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To reiterate from the movie: 3 possible genotypes: H + H + H + H S H S H S In regions without malaria, which genotype has the highest fitness? In regions with malaria, which genotype has the highest fitness? 4
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Which evolutionary forces affect the present- day distribution of sickle cell anemia in human populations? • Mutation Genetic drift Gene flow Natural selection 5
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Evolution is relevant to medicine Human genotypes, including genetic diseases, are the result of evolution Human susceptibility to pathogens often has a genetic basis Pathogens evolve, sometimes very quickly 6
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Genetic diseases e.g., Huntington’s disease (autosomal dominant)
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