L22_2017_realworldgen1_student version220.pdf

L22_2017_realworldgen1_student version220.pdf - BIOL1020...

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BIOL1020 A/Prof Sandie Degnan and A/Prof Cynthia Riginos School of Biological Sciences Lecture 22 ‘Real world genetics I Readings : Campbell 14.3-14.4
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Learning objectives for today s lecture: 1. To gain familiarity with the relationships between genotypes and phenotypes observed in real organisms 2. To recognise and identify common deviations from Mendelian inheritance based on frequencies of progeny (lecture) and pedigrees (in tutorials, next week) 3. To predict offspring phenotypes given parental genotypes Keywords : non Mendelian Inheritance, incomplete dominance, co-dominance, overdominance, pleiotropy, polygenic, epistasis 2
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What is a dominant trait? What is a recessive trait? 3
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What is a dominant trait? What is a recessive trait? Regulatory elements Promoter Protein-coding sequence Final mRNA exon 1 exon 2 exon 1 exon 2 intron Protein Transcription Translation Dominant allele = usually functional as per normal 4
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What is a dominant trait? What is a recessive trait? Regulatory elements Promoter Protein-coding sequence Final mRNA exon 1 exon 2 exon 1 exon 2 intron Protein Transcription Translation Recessive allele = usually lack of normal function (because of a mutation) 5
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Many traits are incompletely (partially) dominant = heterozygote has an intermediate phenotype 6
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1. What is the expected proportion of progeny when two pink snapdragons are crossed?
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