Spermatogenesis.docx - Male endocrinology and...

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Male endocrinology and spermatogenesis 3 Requirements for sperm production Adequate GnRH Pituitary needs to produce LH and FSH Testes need to produce testosterone GnRH bursts are short and are secreted by hypothalamus FSH is low due to inhibin giving a constant negative feedback FSH peak are longer than GnRH Targets Sertoli cells – FSH dependent Testosterone becomes estradiol (role unclear) Negative feedback in the hypothalamus: decreases GnRH and this then decreases FSH and LH Inhibin blocks FSH LH Acts on Leydig cells produces testosterone Pulse prevents desensitization When it produces the testosterone, it can go into the blood stream and also into the Sertoli cell Blood testosterone goes to the hypothalamus for negative feedback Pulsatile LH: needed for proper biological function Increase testosterone in seminiferous tubules essential for spermatogenesis 100-500 times higher than circulation (Counter current exchange) Chronic and high LH, Leydig cells become refractory
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  • Fall '09
  • Spermatogenesis, Sertoli cell, stem cell renewal

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