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5-Neural_Stem_Cell

5-Neural_Stem_Cell - Neural Stem Cell Part I Overview...

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Neural Stem Cell Part I: Overview
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Materials Neural Stem Cells, by Bottenstein: Chapter 4-6 for complementary reading Stem Cells Handbook, By Sell Slides indicated portion Exams will be confined within the class material Reserved in Life Science Library Paterno, 4 th floor Can’t check it out
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Why Study Stem Cells? To understand the cycle of life To study how adult tissues get renewed To explore the use of stem cells as a way of tissue repairing, i.e., “stem cell therapy”. Many diseases don’t have a good treatment today. Stem cells offer a great hope of replacing dead cells or even a failed organ with a newly created one. Treatment for Parkinson’s disease is a good model: grafting stem cells into patients, generate new dopaminergic neurons and relieve symptom up to 10 years.
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2003 Britain becomes the first country to issue research licences for human embryonic cloning to create stem cells. It specifies therapeutic, not reproductive, cloning. 2004 California voters voted to support Proposition 71, designating $3 billion for stem cell research over 10 years. 2004 Harvard University established stem cell research institute to use private fund to do stem cell research. 2004 Britain announces the first embryonic stem cell bank. Many other countries support stem cell research. Stem Cell Research: Hot Issue
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“All cells come from cells.” --Rudolph Virchow A stem cell is a cell that can divide indefinitely and make many or all other specialized cells in the body. Overview of Stem Cells Germinal stem cells persist in the adult to allow the cycle of life to continue. Other stem cells divide to form one cell that remains a stem cell and another cell that differentiates to a mature cell with specialized function, such as blood cell, muscle cell, and neuronal cell. Most cancers arise from stem cells or their immediate progeny. Cancer results from an imbalance between the rate at which cells are produced and the rate at which they differentiate or die.
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