vasculature - independent of nerves or hormones primary...

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Lecture Outline March 21, 2008 Cardiovascular System: Vasculature and blood flow Vasculature Arteries conducting vessels Arterioles resistance vessels Capillaries exchange vessels capacitance vessels Blood flow A. Pressure gradient Systemic circuit Mean arterial pressure ( MAP ) is the average pressure in the aorta throughout the cardiac cycle Central venous pressure ( CVP ) in large veins of thorax leading to right atrium…~2-8 mm Difference is the pressure gradient ( P ) which drives blood flow Pulmonary circuit difference between the pressure in the pulmonary arteries and pulmonary veins pulmonary arterial pressure is ~15 mm Biology 141:Physiology R P F =
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Lecture Outline B. Resistance 1. viscosity of blood 2. vessel length 3. vessel radius Total peripheral resistance (TPR) resistance to blood flow offered by all of the systemic vasculature Control of vasoconstriction/vasodilation Intrinsic (local) control originate from the vessel itself or the surrounding tissue
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Unformatted text preview: independent of nerves or hormones primary function is to regulate the local blood flow 1. myogenic mechanisms 2. endothelial factors 3. paracrines 4. metabolic by-products or hypoxia 5. heat, cold Extrinsic factors originate from outside of the organ or tissue in which the blood vessel is located primary function is to regulate arterial blood pressure by altering systemic vascular resistance a. neural 1 and 2 adrenergic receptors b. hormonal angiotensin II and ADH (vasopressin) vasoconstriction ANF vasodilation E 2 adrenergic receptors Pathologies Atherosclerosis stenosis thrombus (thrombi) Coronary artery disease (CAD) ischemia hypoxia, anoxia infarction Peripheral Arterial Disease (PAD) claudication Strokes embolism Biology 141:Physiology Lecture Outline Aneuryism Biology 141:Physiology...
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vasculature - independent of nerves or hormones primary...

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