N5315-Module 2.1 Fluid and Electrolytes.docx - N5315 Advanced Pathophysiology Fluid and Electrolytes Module 2 part 1 Core Concept and Objectives with

N5315-Module 2.1 Fluid and Electrolytes.docx - N5315...

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N5315 Advanced Pathophysiology Fluid and Electrolytes Module 2 part 1 Core Concept and Objectives with Advanced Organizers Fluid and Electrolytes 1. Analyze the pathologic consequences of fluid volume disorders on the mechanisms of fluid homeostasis.a. Explain the three main fluid compartments and describe how fluid shifts between the compartments and the implications for clinical practice. Fluid Compartments Definition Pattern of Fluid Shifts Clinical Implications Intravascular The intravascular space contains 20% of the total body water. Both in and out of the interstitial and intracellular spaces Hypertonic IV solution, when administered, will increase the solute concentration in the intravascular space. Volume overload Venous retention Increased venous pressure edema Interstitial The interstitial space contains 20% of the total body water. Due to the increase in solute concentration in the intravascular space, water will flow via osmosis from the extracellular space to the intravascular space. This will leave the extravascular space with a higher concentration of solutes than the intracellular space. Fluid will shift from intracellular into the extracellular space (intravascular). Edema: Accumulation of fluid in interstitial space -influenced by increased hydrostatic pressure, low plasma oncotic pressure, increased cap membrane permeability,
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b. Analyze the principles of fluid balance and describe the implications for clinical practice.
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