NURS 6501N-14: Advanced Pathophysiology Week 8: Gastrointestinal System INITIAL POST Digestive Disorders Digestive disorders or disorders of the gastrointestinal system include disorders that can disrupt its functions. Some of these disorders can be due to structural, neural abnormalities, inflammatory and ulcerative conditions (Huether & McCance, 2017, p. 906). Many of these disorders can be averted or minimized by maintaining a healthy lifestyle, practicing good bowel habits, and submitting to cancer screening. Pathophysiological Mechanisms of Inflammatory Bowel Disorder The pathophysiology of inflammatory bowel disease (IBD) is multifactorial caused by a dysregulated immune response to host intestinal microflora. A defective mucosal barrier may result in increased intestinal permeability which promotes the exposition of luminal content and triggers an immunological response that supports intestinal inflammation (Michielan & D'Incà, 2015). In vitro studies have demonstrated that cytokines elaborated by immune cells can cause the mucosal barrier to become leaky (Clayburgh, Shen, & Turner, 2004). The two major types of inflammatory bowel disease are ulcerative colitis (UC), which is limited to the colonic mucosa, and Crohn disease (CD), which can affect any segment of the gastrointestinal tract from the mouth to the anus (Michielan & D'Incà, 2015). IBD runs a waxing and waning course. During severe inflammation, the disease is active and presents a flare-up of symptoms, such as persistent, bloody diarrhea, abdominal cramps and pain, rectal bleeding/bloody stools, weight loss, fatigue and fever. During the waning or remission, there are no symptoms. Pathophysiological Mechanisms of Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders that affects the function and behavior of the intestines. Typically, the muscles lining the intestines contract and relax to move food along the digestive tract. In IBS, this pattern is disturbed, resulting in uncomfortable symptoms. IBS is characterized by bloating, cramping, gas, mucus in the stool, abdominal distension, abdominal pain and disturbed defecation (diarrhea and/or constipation) that cannot be explained by structural or biochemical abnormalities. IBS is considered a gut motor disorder. A number of motor abnormalities have been described in the colon and small bowel of IBS patients. Barbara, De Giorgio, Stanghellini, Cremon, Salvioli, and
You've reached the end of your free preview.
Want to read all 7 pages?
- Fall '17
- keisha lovence
- Gastroenterology, Irritable bowel syndrome, Ulcerative colitis, Inflammatory bowel disease, bowel disease