PEPTIC ULCER DISEASE AND TREATMENT SAEEDA SULTANA SOUTH UNIVERSITY NSG6005 PHARMACOLOGY
PEPTIC ULCER Peptic ulcers are the erosion of inside lining of the stomach and the upper portion of the small intestine due to excessive acid exposure which associated with stomach pain. The peptic ulcer disease divided into: Gastric Ulcers: that occur when the gastric acid destruct the lining of the stomach. Duodenal Ulcers: develop when the upper portion of the small intestine (duodenum) expose with acid. It is more common than a stomach ulcer. Esophageal Ulcers: are rare and often occur due to the prolong use of some medications and alcohol (Anand & Katz, 2017).
CAUSES OF PEPTIC ULCER Approximately one of every 8 Americans will develop peptic ulcer. H. pylori infection Misuse of OTC painkillers such as aspirin, ibuprofen, and naproxen Other medication such as steroids, anticoagulants, selective serotonin reuptake inhibitors (SSRIs), alendronate (Fosamax) and risedronate (Actonel), can upsurge the risk of developing ulcers (Centers for Disease Control and Prevention, 2016).
RISK FACTORS OF PEPTIC ULCER Life stress (Young Bok, Jihan, Ho & Seok, 2017). Spicy rich fast food, caffeine Heavy alcohol use Smoking Genetic predisposition to excessive stomach acid secretion Cancerous stomach ulcers are more prevalent in people with type A blood group
RISK FACTORS OF PEPTIC ULCER (CONT…) Duodenal ulcers are more common in people with type O blood group. A recent study confirm that the main reason for peptic ulcers is bacterial infection. Indeed, the bacterium Helicobacter pylori (H. pylori) cause approximately 89% of duodenal ulcers and 79% of gastric ulcers. Another study shows that older people are more prone to develop stomach ulcers because they take high dose of the NSAIDs to alleviate the arthritis pain. In old age, the pyloric valve at the end of the stomach relaxes and allow the bile to leak into the stomach and eat away the stomach wall (Anand et al., 2017).
SYMPTOMS OF PEPTIC ULCER
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- Fall '16
- Helicobacter pylori, Gastric Ulcers