Parkinson Disease final.docx - Parkinsons Disease...

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Parkinson’s Disease Parkinson’s disease (PD) is a neurodegenerative disorder that affects predominately dopamine-producing (“dopaminergic”) neurons in a specific area of the brain called substantia nigra 1 . Parkinson’s disease affects one in 100 people over the age of 60, the average onset is 60 years old. For this degenerative disease the symptoms develop slowly over the years. The progression of Parkinson’s disease varies from person to person. In the early stages of Parkinson’s some symptoms you may experience are, cramped handwriting or general writing changes, tremors mostly focusing on the hand and foot, uncontrollable movements during sleep, bradykinesia which is slow movement, ridged facial expression, and stooped posture 2 . As symptoms get worse, people with the disease may have trouble walking, talking, or doing simple tasks. People with Parkinson’s may develop depression, sleeping problems and have motor problems. Dementia is very common with people with this disease, it occurs during the later stages of Parkinson’s 3 . The cause of Parkinson’s disease currently is still unknown, however, there is evidence to believe that genetics, environmental factors, and the two-combined play a big role in causing this disease. Parkinson’s is caused by a single gene mutation and because this is an autosomal- dominant disorder, one mutated allele of the gene is enough to cause the disease. It is estimated that only 10% of these cases are due to genetic causes. The most known gene mutation that

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