PSY71- Drugs & Psychosis

PSY71- Drugs & Psychosis - The Dopamine Hypothesis...

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1 The Dopamine Hypothesis – Carlsson and Lindquist (1963): DA antagonsists reduce positive symptoms of schizophrenia. Therefore schizophrenia due to too much dopamine. – Other specific drugs: dopamine (agonists), L-Dopa (Parkinsons’s) result in schizophrenic-like behavior – Amphetamines activate dopamine system and produce +ve symptoms – ?? SCHIZOPHRENIA: TOO MUCH DOPAMINE?? Traditional Antipsychotic drugs Began with Chlorpromazine: early 50s. Mainstay of treatment Pre-90s • D2 Blockers • Potency proportional to D2 blockade • But ‘Neuroleptic’ Many people with schizophrenia are not helped by neuroleptics or dopamine antagonists Although neuroleptics block dopamine receptors quickly, symptoms take days - weeks to subside Neuroleptics due little to help with negative symptoms or neurocognitive symptoms CLOZAPINE: produced more symptom relief than strong dopamine antagonists, YET a poor D2 antagonist BUT…
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2 The story of Clozapine First introduced in 1975 in Europe
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This note was uploaded on 03/26/2008 for the course PSYCH 71 taught by Professor Kuperberg during the Spring '08 term at Tufts.

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PSY71- Drugs & Psychosis - The Dopamine Hypothesis...

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