KEY_HW7_17.pdf - KEY_HW#7_Fall 2017 Molecules and Cells 1...

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Chapter 9 / Exercise 9.67
Chemistry for Engineering Students
Brown/Holme
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KEY_HW#7_Fall 2017 Molecules and Cells 1. Metabolic Mutants: Predict the effect of each of the following on the pace of glycolysis in liver cells (increase the rate of glycolysis, decrease the rate, or no change). Explain your answers. a. Loss of the allosteric site for ATP in phosphofructokinase b. Loss of the binding site for citrate in phosphofructokinase c. Loss of the binding site for fructose 1,6-biphosphate in pyruvate kinase. d. Increase in the concentration of fructose 2,6-bisphosphate e. Increase in the concentration of ATP
1 2. When (dinitrophenol) DNP is added to mitochondria, the inner membrane becomes permeable to protons. When the drug valinomycin is added to the mitochondria, the inner membrane becomes permeable to K+. a. How will the proton motive force change in response to DNP (increase, decrease, or no change)? Explain your answer. b. What do you think will happen to the temperature of the system with DNP (increase, decrease, remain the same)? Explain your answer.
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Chemistry for Engineering Students
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Chapter 9 / Exercise 9.67
Chemistry for Engineering Students
Brown/Holme
Expert Verified
KEY_HW#7_Fall 2017 Molecules and Cells c. DNP was once prescribed as a diet drug to aid weight loss. How would DNP promote weight loss? Why do you suppose that it is no longer prescribed? d. How will the proton motive force change in response to valinomycin? Explain your answer.
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3. Muscle contraction causes an immediate increase in the rate of oxidative phosphorylation because it (explain your answer)

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