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Nurs 6501Week 5 Discussion 2Progression of Anaphylactic ShockAnaphylactic shock results from an extensive allergic reaction known as anaphylaxis. It ischaracterized by other effects that quickly involve the whole body and referred to symptoms triggered by immunoglobulin (Ig) E–dependent activation of immune effector cells (Huether & McCance, 2017). Triggering immunoglobulin (Ig) E causes the release of numerous mediators involving histamine, prostaglandins, and kinins. These mediators prompt increased capillary which prompts peripheral pooling and tissue edema and relative hypovolemia. This is surmounted by diminished Systemic vascular resistance (SVR), with decreased tissue perfusion, impaired cellular metabolism, and reduce cardiac output and oliguria. Together with these issues is extravascular effects include constriction of extravascular smooth muscle, often causing laryngospasm, cramping abdominal pain with diarrhea and bronchospasm (Huether & McCance, 2017).