Week 7 Discussion PostHematological SystemAnemiaAnemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. For the sake of this discussion, I’m going to discuss the pathophysiological mechanisms of sideroblastic anemia. I will then describe the similarities and differences between iron deficiency anemia and sideroblastic anemia and the factors of genetics, gender, ethnicity, and age related to it. Pathophysiology of Iron Deficiency Anemia and Sideroblastic AnemiaAccording to Huether & McCance (2017), iron deficiency anemia (IDA), is the most common type of anemia throughout the world, occurring in developing and developed countries. Sideroblastic anemias (SAs) are a heterogenous group of inherited and acquired disorders characterized by anemia of varing severity and presence of ringed sideroblasts in the bone marrow (Huether & McCance, 2017). Furthermore, SA is similar to IDA because it also involves alteration in iron; however, SA is due to iron overload, whereas, IDA is due to iron deficiency (Huether & McCance, 2017). According to Huether & McCance (2017), IDA develops through 3 different stages. In Stage I, the body’s iron stores for red cell production and hemoglobin synthesis are depleted, however, the red cell production proceeds normally with the
hemoglobin content of red cells also remaining normal (Huether & McCance, 2017). In stage II, insufficient amounts of iron are transported to the marrow, and iron-deficient redcell production begins (Huether & McCance, 2017). Stage III begins when the hemoglobin deficient red cells enter the circulation to replace normal, aged erythrocytes that have been destroyed (Huether & McCance, 2017).
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- Spring '15
- Hemoglobin, Vitamin B12, Huether, deficiency anemia