Discussion 4.docx - Bibliography Thomas M Sing H Belenky G...

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Bibliography Thomas, M., Sing, H., Belenky, G., Holcomb, H., Mayberg, H., Dannals, R., . . . Welsh, A. (2000). Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. Journal of Sleep Research , 335-352. In this study, researchers asserted that sleep deprivation has a direct negative effect on alertness and cognition due to decreased brain activity and function in the thalamus and the prefrontal cortex. To test this theory, researchers performed PET (positron emission tomography), and FDG (Fluorine-2-deoxyglucose) scans at multiple stages of sleep deprivation. Initial scans were performed and then repeated in 24 hour intervals leading to 84 hours of sleep deprivation. Subjects were required to perform math tasks during these scans. Researchers found that just 24 hours of sleep deprivation resulted in a decrease of cerebral metabolic rate for glucose (CMRglu) globally with significant decreases predominantly in the thalamus and

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