Week 01 - Escherichia Coli

Week 01 - Escherichia Coli - elephant.” Jacques Monod •...

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1 Microbe of the Week #1 Escherichia coli E. coli is a common inhabitant of the digestive system of warm-blooded animals. • We know more about the biology of than any other organism. • Some strains can cause serious diseases of humans and animals. Microcolony of Produced from a single cell in 11.5 hrs at 37 C. is a gram negative, rod- shaped bacterium cell disrupted to release DNA. A cell 2-3 μm long contains 1.2 mm of DNA. Flagella (above) and fimbriae (below) surround the cells. A typical cell is 1 X 3 μm. A common inhabitant of our intestines. .. • Each gram of feces contains 10 8 - 10 9 E. coli cells. and other microflora of the gut provide vitamins (K and B-complex). • Gut microflora protects against opportunistic pathogens. False color scanning electron micrograph of E. coli cells. "Once we understand the biology of Escherichia coli , we will understand the biology of an
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Unformatted text preview: elephant.” Jacques Monod. • is the most intensively studied organism on the planet. • An important model system in microbiology, biochemistry, genetics, etc. • An indispensable tool in genetic engineering. • Complete DNA genome sequence published in 1997. • Program is underway to catalog all the proteins that it produces ( proteome project). Some strains of cause serious disease. .. • Pathogenic strains produce toxic chemicals that allow them to infect the host. • Some strains cause tremendous child mortality in developing world. • Strain 0157 is a foodborne pathogen that can cause serious intestinal and kidney disease. Electron micrograph of 0157:H7...
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