Bio82 Syllabus Sep 22.pdf

Bio82 Syllabus Sep 22.pdf - Bio 82 Genetics Fall 2017 Tue...

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1 Bio 82- Genetics Sep 22, 2017 Fall, 2017 Tue, Thu 9:00 am–10:20am STLC (Science Teaching and Learning Center) 111 Instructors Professor Dominique Bergmann ([email protected]) Professor Michael Simon ([email protected]) Office hours: To be posted on Canvas Bio 82 Teaching Assistants Claire Baumer ([email protected]) Delaney Sullivan ([email protected]) Kade Pettie ([email protected]) Mauricio Aguilar [email protected] Michelle Pang ([email protected]) Mike Guernsey ( [email protected]) Victoria Gomez ([email protected]) Office hours: To be posted on Canvas Foundations Administrative Course Assistant Allison Brown ([email protected]) Foundations Lecturer Waheeda Khalfan ([email protected]) Short Course Description The focus of the course is on the basic mechanisms underlying the transmission of genetic information and on the use of genetic analysis to study biological and medical questions. Major topics will include: (1) the use of existing genetic variation in humans and other species to identify genes that play an important role in determining traits and disease-susceptibility, (2) the analysis of mutations in model organisms and their use in the investigation of biological processes and questions and (3) using genetic information for diagnosis and the potential for genetic manipulations to treat disease. Prerequisites: None
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2 Course schedule The schedule below is tentative and will be updated and adjusted based on the pace at which we cover the material! You are responsible for checking the updated schedule on Canvas. Readings associated with the lectures will also be posted on Canvas. Date Day Instructor Topic Assignments due that week Week 1 (9/25-10/1) 9/26 Tue Bergmann What is modern genetics? Concepts of genes, genotypes and phenotypes Pre-section 1 due Sun 10/1 at 11:59:00pm 9/28 Thu Bergmann Dominance relationships among alleles Course logistics (TAs, syllabus review) Week 2 (10/2-10/8) 10/03 Tue Bergmann Defining genes at a biochemical level Pre-section 2 due Sun 10/8 at 11:59:00pm 10/05 Thu Bergmann Accurately transmitting genetic information from cell to cell and generation to generation Week 3 (10/9-10/15) 10/10 Tue Bergmann Linking genotype to phenotype at molecular and functional levels Pre-section 3 due Sun 10/15 at 11:59:00pm 10/12 Thu Simon Introduction to gene mapping: How do we measure the “distance” between genes? Week 4 (10/16-10/22) 10/17 Tue Simon What is a genetic map and how is it constructed? Post-Section 1 due Wed 10/18 at 11:59:00pm Pre-section 4 due Sun 10/22 at 11:59:00pm 10/19 Thu Simon Mapping Simple Mendelian Traits in Humans: The basics of pedigrees. Week 5 (10/23-10/29) 10/24 Tue Simon Mapping Simple Traits in Humans: SNPs and VNTR markers and their use in genetic mapping. Post-Section 2 due Wed 10/25 at 11:59:00pm Pre-section 5 due Sun 10/29 at 11:59:00pm 10/26 Thu Simon Mapping Simple Traits in Humans: LOD score analysis of pedigrees
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3 Date Day Instructor Topic Assignment/s Due that week Week 6 (10/30-11/5) 10/31 Tue Simon Why do mapping experiments sometimes go bad? Pre-section 6 will be due after exam (see below) 11/02
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