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12 - Chromosomes contain a protein made of amino...

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Chromosomes contain: a) protein made of amino acids (about 20) b) deoxyribonucleic acid (DNA) made of nucleotides (4) I. Molecular Genetics A) Finding the Code 1) Griffith – pneumonia experiments (1928) Trying to develop a vaccine for pneumonia Working with pathogenic (potentially fatal) & non-pathogenic bacteria * He found: Transformation Non-pathogenic bacteria was transformed into pathogenic bacteria; they reproduced as fatal bacteria; the genetic makeup was changed 2) Avery, McCarty and MacLeod (1944) Only pathogenic DNA needed for transformation Take non-pathogenic bacteria, add DNA from pathogenic bacteria * Important evidence that DNA might be genetic material 3) Hershey and Chase – bacteriophage (virus that attacks bacteria) (1952) Virus goes to cell and manages to take over your cell in such a way that inside the cell many new viruses are made Clearly w/e goes into bacteria must be the viruses’ genetic material - Labeled DNA with P 32 (found inside) - Labeled protein with S 35 (found outside)
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