Research Exploration Assignment 1

Research Exploration Assignment 1 - Sam Seider Brian Asen...

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Sam Seider Brian Asen Bio 150 11 March 2008 Research Exploration Assignment 1 Faculty Host and Department: Dr. Jeff Ross, McArdle Cancer Research Lab Research Exploration Title: Regulation of mRNA stability in mammalian cells Essay: The focus of my lab experience was on the extremely intriguing, yet incredibly complex world of RNA. As a group we got to witness the influence that RNA and specific proteins have on various cancerous cells. The experiments conducted were multifaceted but understandable. We studied how messenger RNA turnover influences gene expression and how mRNA-binding proteins influence mRNA translation and stability. This understanding led to the explanation of the PCR machine which created exponential amounts of the same strand of DNA which were then studied. The importance of the protein and mRNA is easily seen in the actual experiments. In cancerous mice, the protein—with the mRNA as a catalyst—was overexpressed in the colon, lung, and breast tissue. This interesting correlation leads to some of the questions that Dr. Ross
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This note was uploaded on 03/27/2008 for the course BIO 150 taught by Professor Grinblat during the Winter '07 term at Wisconsin.

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Research Exploration Assignment 1 - Sam Seider Brian Asen...

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