Lec 3 Complement

Lec 3 Complement - just B as part of the C3bB complex? C3b...

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Complement
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Overview Components Biological activity Activation pathways Active intermediates
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Components What is the biochemical nature of complement? (proteins, polysaccharides…?) How many different molecules? Where are they made? Where are they found?
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Biological Activity of Activated Complement Lysis of targeted cells Enhancement of phagocytosis (opsonization)- through enhancement of which step in phagocytosis? Stimulation of inflammation Chemotaxis of phagocytic cells Altered capillary permeability
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Activation Pathways Classical (Antibody-mediated) Alternate Lectin pathway (Mannose-binding protein)
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C3b C3a C3 C3 C3b C3a Alternate Pathway C3 spontaneously breaks down into C3a and C3b What are the properties of these fragments? What happens to C3b in the presence of a microbial cell?
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C3b C3a B D Bb Ba Alternate Pathway C3b binds B. Does C3 bind B? Factor D converts C3bB to C3bBb and Ba. Does Factor D recognize B alone, or
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Unformatted text preview: just B as part of the C3bB complex? C3b Bb P C3a Alternate Pathway Properdin (factor P) stabilizes C3bBb C3bBb = C3 convertase Convertase catalyzes conversion of many molecules of C3 C3b Bb P Alternate Pathway C3b may bind to C3bBb, producing C3b 2 Bb C3b 2 Bb = C5 convertase C5 convertase catalyzes C5 --> C5a +C5b C5 C5b C5a Alternate Pathway C5b C6 C8 C7 C9 Formation of membrane attack complex (MAC) Initiated by? Lysis of targeted cell due to ? Does this MAC differ from a MAC produced through the classical pathway or the lectin pathway? Complement Activation What biologically active complement components are produced via alternate pathway? via classical pathway? via lectin pathway? How is the classical pathway initiated? How is a C3 convertase produced? How is the lectin pathway initiated?...
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This note was uploaded on 03/27/2008 for the course MB 451 taught by Professor M during the Fall '07 term at N.C. State.

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Lec 3 Complement - just B as part of the C3bB complex? C3b...

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