Lec 6 New B cell diff

Lec 6 New B cell diff - B Cell Differentiation...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
B Cell Differentiation B Cell Differentiation Immunogenetics Immunogenetics Antigen independent differentiation into Antigen independent differentiation into naïve B cells naïve B cells Gene rearrangements at immunoglobulin loci Gene rearrangements at immunoglobulin loci for light and heavy chains for light and heavy chains Antigen Antigen T cell independent antigens --> IgM T cell independent antigens --> IgM T cell dependent antigens --> immunoglobulin T cell dependent antigens --> immunoglobulin class switching class switching
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
B Cell Differentiation Stem cell Bone marrow Gene rearrangements Expression of IgD & IgM (monomeric) on surface Secondary lymphoid tissue Naïve B cell Antigenic stimulation + T helper cell help No more antigen Apoptosis or differentiation into memory cells Antibody synthesis
Background image of page 2
Antibody Structure Antibody Structure
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Antibody Structure Antibody Structure
Background image of page 4
2 3 10 15 20 30 40 1
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 17

Lec 6 New B cell diff - B Cell Differentiation...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online