Lec 12-2 - Decrease cell migration into tissues •...

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Autoimmune Disease Autoimmunity: when tolerance is broken - immune response to self antigens Immunodeficiencies: acquired or inherited impairment of innate or specific immunity Complement components Immunoglobulins B and T cells
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Autoimmunity Causes/stimuli Unknown Genetic component (HLA loci) Infections - stimulation through cross-reacting antigens Examples Systemic Lupus Erythematosus - Antibody against many nuclear antigens (Immune complex) Diabetes (Type I) - TH1 and CD8 T cell responses to pancreatic beta cells
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Immunofluorescent staining of IgG at dermal/epidermal junction Immunofluorescent staining of C1 in glomerulus of kidney http://medlib.med.utah.edu/WebPath/TUTORIAL/SLE/SLE.html SLE
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Treatments/Immunosuppression Corticosteroids Ex.: Prednisone Decrease cytokines
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Unformatted text preview: Decrease cell migration into tissues • Cyclosporin A – Inhibits T cell activation • Antibody against cytokines – Ex.: Anti-TNF in treatment of rheumatoid arthritis Anti-TNF therapies • Inflixomab: Mouse-human IgG1 anti-TNF monoclonal antibody • Adalimumab: Human recombinant anti-TNF monoclonal antibody • Etanercept: Recombinant human soluble TNF receptor Immunodeficiencies • Complement deficiencies – C1-C3 & alternate pathway components – C5-C9 • Phagocytosis deficiencies – Chediak-Higashi syndrome: oxidative killing – Chronic granulomatous disease: phagosome/lysosome fusion Immunodeficiencies • B cell – Lack of B cells – Lack of Ig switching • T cell – Lack of T cells due to lack of thymus or TCR development • Combined deficiencies – Lack of recombination at Ig and TCR loci...
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This note was uploaded on 03/27/2008 for the course MB 451 taught by Professor M during the Fall '07 term at N.C. State.

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Lec 12-2 - Decrease cell migration into tissues •...

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