Antibody Mediated Immunity To complete this worksheet, select: Module: Disease Resistance Activity: Animations Title: Antibody Mediated Immunity Introduction 1. a. Explain B-cell (B-lymphocyte) role with antibody-mediated immunity. When a foreign antigen is present specific B cells in the lymph nodes, spleen or mucosa lymphatic tissue become activated. They differentiate into plasma cells that secrete specific antibodies which circulate in the lymph and blood to reach the site of invasion. b. Describe the role of lymph nodes and spleen in this process. Lymph nodes and the spleen contain/House the B cells. B Cell Activation, Proliferation and Differentiation 2. a. Describe the importance of the immunoglobulin receptors on the surface of B-cells. B cell receptors bind to antigens and helper T cells recognize the antigen and deliver the co-stimulation needed for B cell proliferation and differentiation. b. Why are millions of different receptor shapes essential to their function? In order to produce offspring with the combinations and traits that differ from those found in either parent.