hms_8543

hms_8543 - Harvard-MIT Division of Health Sciences and...

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Harvard-MIT Division of Health Sciences and Technology HST.512: Genomic Medicine Prof. Atul Butte Please see Proc Natl Acad Sci U S A. 2003 Jul 8;(100)14:8466-71. Epub 2003. Jun 27 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 Patti ME, et. al. Question •± Can we define patterns of gene expression in human subjects with diabetes and those at high risk for development of diabetes? •± Mexican-American subjects •± Stratified by diabetes and family history •± Diabetics treated with lifestyle changes or sulfonylureas •± No exercise for 48 hours •± Fasting biopsy of vastus lateralis
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Results j FH- FH+ DM Unequal variance, unpaired t-test, p < 0.05 None significant after Ben amini-Hochberg correction 55 intersecting genes Many coded for mitochondrial proteins involved in ATP synthesis and oxidative phosphorylation 187 / 7129 different 166 / 7129 different
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Web-accessible data •± Great amounts of publicly available microarray data are available on the Internet •± CardioGenomics Program in Genomic Applications http://cardiogenomics.med.harvard.edu/public-data.html –± 142 microarrays involving mouse models of cardiac development and signal transduction, including measurements made in time- series. •± Whitehead Institute Center for Genome Research – http://www-genome.wi.mit.edu/cgi-bin/cancer/datasets.cgi –± Microarrays from 12 publications involving many types of cancer, including some clinical measurements associated with each sample. Web-accessible data •± Children’s National Medical Center (HopGenes Program in Genomic Applications) http://microarray.cnmcresearch.org/pgadatatable.asp –± Over 500 microarrays from many human diseases, including muscular dystrophy, dermatomyositis, and heart failure, as well as
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hms_8543 - Harvard-MIT Division of Health Sciences and...

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