Outline-Key Concepts 12-10

Outline-Key Concepts 12-10 - Outline & Key Concepts:...

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I. Menopause—Take home messages II. Breast Cancer a. Statistics i. Incidence & Mortality ii. Potential Causes of Disparities b. Environmental Connection—Four lines of evidence i. Dramatic differences in incidence between communities ii. Changes in incidence for groups that migrate to a new country iii. Changes in incidence for particular types of cancer over time iv. Existence of known carcinogenic substances 1. Pesticides 2. Radiation 4. Dioxins 5. Hormones c. Screening i. Mammography ii. MRIs d. Medicalizing Prevention i. Early detection is not prevention! ii. Chemoprevention a. SERMS: Selective Estrogen Receptor Modulators i. Tamoxifen (Nolvadex) 1. Breast Cancer Prevention Trial 2. Important questions/considerations ii. Raloxifene (Evista) 1. Far less studied 2. Osteoporosis 3. No endometrial cancer risks but still sig nif increase in blood glots and stroke like tamoxifen iii. Block effects of estrogen way they reduce cancer—why
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Outline-Key Concepts 12-10 - Outline & Key Concepts:...

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