2212 Lecture 22 Oct 19.ppt - Friday October 19th Regulation...

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Regulation of Bacterial Gene Expression Friday, October 19th I Metabolic Control A. Feedback inhibition B. Transcriptional regulation II Operon A. Trp operon structure 1. Operator B.Function 1. Repressible operon 2. Repressor 3. Corepressor C. Repressible enzyme 1. Anabolic pathways III Lac Operon A. Lac operon structure B. Lac operon function 1. Repressor 2. Inducer 3. cAMP 4. Catabolite activator protein (CAP) C. Inducible ezyme 1. Catabolic pathways
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Precursor Feedback inhibition Enzyme 1 Enzyme 2 Enzyme 3 Tryptophan (a) (b) Regulation of enzyme activity Regulation of enzyme production Regulation of gene expression trpE gene trpD gene trpC gene trpB gene trpA gene Allows for adjustment in the short-term For longer term regulation and conservation of resources
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Promoter DNA Regulatory gene mRNA trpR 5 3 Protein Inactive repressor RNA polymerase Promoter trp operon Genes of operon Operator mRNA 5 Start codon Stop codon trpE trpD trpC trpB trpA E D C B A Polypeptide subunits that make up
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  • Fall '18
  • Rhonda Nicholson
  • DNA, trp operon

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